Gene information
Official symbol IL2RA
Official full name interleukin 2 receptor subunit alpha
Gene type protein-coding gene
Chromosome10p15.1
Alias symbolCD25
Previous symbolIL2R; IDDM10
Gene familyCD molecules; Interleukin receptors; Sushi domain containing
Resources
Entrez Gene 3559
HGNC HGNC:6008
Ensembl ENSG00000134460
Vega OTTHUMG00000017616
UCSC uc001iiz.3
GO terms: 62 records
GO Description Category LogP Number of genes Detail
GO:0001776 leukocyte homeostasis GO Biological Processes -5.24665798 8 More
GO:0002260 lymphocyte homeostasis GO Biological Processes -3.29518609 9 More
GO:0002437 inflammatory response to antigenic stimulus GO Biological Processes -7.96781477 8 More
GO:0002643 regulation of tolerance induction GO Biological Processes -2.66836941 3 More
GO:0002683 negative regulation of immune system process GO Biological Processes -26.6415063 77 More
GO:0002694 regulation of leukocyte activation GO Biological Processes -32.0887020 60 More
GO:0002695 negative regulation of leukocyte activation GO Biological Processes -9.84552767 31 More
GO:0002696 positive regulation of leukocyte activation GO Biological Processes -27.9249645 47 More
GO:0004896 cytokine receptor activity GO Molecular Functions -9.30297759 21 More
GO:0006954 inflammatory response GO Biological Processes -86.5569367 100 More
GO:0007162 negative regulation of cell adhesion GO Biological Processes -21.5212108 58 More
GO:0007219 Notch signaling pathway GO Biological Processes -2.15030944 11 More
GO:0008285 negative regulation of cell population proliferation GO Biological Processes -53.5569125 147 More
GO:0019221 cytokine-mediated signaling pathway GO Biological Processes -27.5840932 43 More
GO:0019838 growth factor binding GO Molecular Functions -18.6841278 23 More
GO:0019955 cytokine binding GO Molecular Functions -19.1485102 24 More
GO:0022407 regulation of cell-cell adhesion GO Biological Processes -32.4337382 53 More
GO:0022408 negative regulation of cell-cell adhesion GO Biological Processes -15.9068791 40 More
GO:0022409 positive regulation of cell-cell adhesion GO Biological Processes -25.7751074 39 More
GO:0030155 regulation of cell adhesion GO Biological Processes -41.8400792 131 More
GO:0031347 regulation of defense response GO Biological Processes -64.5971043 148 More
GO:0031348 negative regulation of defense response GO Biological Processes -30.3795513 65 More
GO:0032102 negative regulation of response to external stimulus GO Biological Processes -54.2675416 110 More
GO:0032944 regulation of mononuclear cell proliferation GO Biological Processes -24.6915018 34 More
GO:0032945 negative regulation of mononuclear cell proliferation GO Biological Processes -3.06905273 11 More
GO:0032946 positive regulation of mononuclear cell proliferation GO Biological Processes -20.2231223 25 More
GO:0042102 positive regulation of T cell proliferation GO Biological Processes -13.4787271 17 More
GO:0042104 positive regulation of activated T cell proliferation GO Biological Processes -7.12111476 7 More
GO:0042129 regulation of T cell proliferation GO Biological Processes -18.0871480 25 More
GO:0042130 negative regulation of T cell proliferation GO Biological Processes -2.70311986 5 More
GO:0043029 T cell homeostasis GO Biological Processes -2.57451150 6 More
GO:0045580 regulation of T cell differentiation GO Biological Processes -7.18541630 25 More
GO:0045619 regulation of lymphocyte differentiation GO Biological Processes -8.78322888 17 More
GO:0045621 positive regulation of lymphocyte differentiation GO Biological Processes -6.96534841 12 More
GO:0045785 positive regulation of cell adhesion GO Biological Processes -29.6368249 50 More
GO:0046006 regulation of activated T cell proliferation GO Biological Processes -6.86981007 8 More
GO:0048872 homeostasis of number of cells GO Biological Processes -12.0072872 22 More
GO:0050670 regulation of lymphocyte proliferation GO Biological Processes -22.6006415 32 More
GO:0050671 positive regulation of lymphocyte proliferation GO Biological Processes -19.1485102 24 More
GO:0050672 negative regulation of lymphocyte proliferation GO Biological Processes -2.56497893 10 More
GO:0050727 regulation of inflammatory response GO Biological Processes -68.5964592 121 More
GO:0050728 negative regulation of inflammatory response GO Biological Processes -31.0556128 55 More
GO:0050863 regulation of T cell activation GO Biological Processes -20.3209154 36 More
GO:0050865 regulation of cell activation GO Biological Processes -40.6877761 71 More
GO:0050866 negative regulation of cell activation GO Biological Processes -13.9027363 39 More
GO:0050867 positive regulation of cell activation GO Biological Processes -31.2431659 51 More
GO:0050870 positive regulation of T cell activation GO Biological Processes -17.6497748 28 More
GO:0051249 regulation of lymphocyte activation GO Biological Processes -22.6120519 46 More
GO:0051250 negative regulation of lymphocyte activation GO Biological Processes -7.76846228 25 More
GO:0051251 positive regulation of lymphocyte activation GO Biological Processes -20.2181987 37 More
GO:0070663 regulation of leukocyte proliferation GO Biological Processes -26.8242532 37 More
GO:0070664 negative regulation of leukocyte proliferation GO Biological Processes -3.96184640 13 More
GO:0070665 positive regulation of leukocyte proliferation GO Biological Processes -21.5362473 27 More
GO:0071345 cellular response to cytokine stimulus GO Biological Processes -39.647808 70 More
GO:0140375 immune receptor activity GO Molecular Functions -8.53513203 25 More
GO:1902105 regulation of leukocyte differentiation GO Biological Processes -18.8286876 32 More
GO:1902107 positive regulation of leukocyte differentiation GO Biological Processes -14.6775052 22 More
GO:1903037 regulation of leukocyte cell-cell adhesion GO Biological Processes -23.2079690 66 More
GO:1903038 negative regulation of leukocyte cell-cell adhesion GO Biological Processes -10.2281373 27 More
GO:1903039 positive regulation of leukocyte cell-cell adhesion GO Biological Processes -20.7355312 32 More
GO:1903706 regulation of hemopoiesis GO Biological Processes -16.2759166 33 More
GO:1903708 positive regulation of hemopoiesis GO Biological Processes -14.6775052 22 More
KEGG pathways: 10 records
KEGG Description Category LogP Number of genes Detail
hsa04060 Cytokine-cytokine receptor interaction KEGG Pathway -61.0014447 66 More
hsa04061 Viral protein interaction with cytokine and cytokine receptor KEGG Pathway -30.3399237 29 More
hsa04151 PI3K-Akt signaling pathway KEGG Pathway -29.3006421 73 More
hsa04630 JAK-STAT signaling pathway KEGG Pathway -14.4088859 21 More
hsa04640 Hematopoietic cell lineage KEGG Pathway -11.4657972 15 More
hsa04658 Th1 and Th2 cell differentiation KEGG Pathway -5.18694144 15 More
hsa04659 Th17 cell differentiation KEGG Pathway -9.80516906 14 More
hsa05162 Measles KEGG Pathway -4.80674483 10 More
hsa05166 Human T-cell leukemia virus 1 infection KEGG Pathway -5.08552863 13 More
hsa05200 Pathways in cancer KEGG Pathway -30.6393212 92 More
Drug-Gene interaction
view
Related drugs: 28 records
Drug name Interaction type Source PMID View
aldesleukin modulatoragonist TdgClinicalTrialChemblInteractionsTENDNCI 175845971676792010207608168640891175235217216565175300239167045 view
atorvastatin NCI 16207471 view
basiliximab antibodyinhibitor TdgClinicalTrialChemblInteractionsTENDTTD 12591363169083181056795696957211175235210512062 view
bryostatin NCI 10988359 view
caffeine NCI 3129507 view
cetirizine NCI 7591422 view
cladribine NCI 9619876 view
daclizumab antibodyinhibitor TdgClinicalTrialChemblInteractionsTEND 1690831819788505163048571175235286009441060768917564638 view
decitabine NCI 15814281 view
denileukin diftitox binder ChemblInteractions 186840573124610171875162786749117523521713928417016423 view
didanosine NCI 1774603 view
dinitrochlorobenzene NCI 9607619 view
fluorouracil NCI 9238541 view
flutamide NCI 11312147 view
garlic NCI 10737264 view
inolimomab antagonist ChemblInteractionsTTD view
lentinan NCI 10681809 view
lmb-2 ChemblInteractionsTTD view
mercaptopurine NCI 1580639 view
methimazole NCI 764757117605238340196 view
methylprednisolone NCI 8981122 view
paclitaxel NCI 16595340 view
progesterone NCI 12405159 view
propylthiouracil NCI 8340196 view
staurosporine NCI 1560050 view
theophylline NCI 3129507 view
thyroxine NCI 15068404 view
verapamil NCI 2645720 view
Related study: 1 record
Molecular factor Omics type Application Objective MI type Reference
interleukin-2 receptor subunit alpha proteomics subsequent myocardial infarction[prognosis (bad)] acute myocardial infarction Blum A et al. Am Heart J. 1994
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